Structures of a platelet-derived growth factor/propeptide complex and a platelet-derived growth factor/receptor complex
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چکیده
منابع مشابه
Structures of a platelet-derived growth factor/propeptide complex and a platelet-derived growth factor/receptor complex.
Platelet-derived growth factors (PDGFs) and their receptors (PDGFRs) are prototypic growth factors and receptor tyrosine kinases which have critical functions in development. We show that PDGFs share a conserved region in their prodomain sequences which can remain noncovalently associated with the mature cystine-knot growth factor domain after processing. The structure of the PDGF-A/propeptide ...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2010
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.1000806107